Friday, October 18, 2013

U.S. Congress ends default threat, Obama signs debt bill


By Richard Cowan and David Lawder


WASHINGTON (Reuters) - The U.S. Congress on Wednesday approved an 11th-hour deal to end a partial government shutdown and pull the world's biggest economy back from the brink of a historic debt default that could have threatened financial calamity.


Capping weeks of political brinkmanship that had unnerved global markets, President Barack Obama quickly signed the spending measure, which passed the Senate and House of Representatives after Republicans dropped efforts to use the legislation to force changes in his signature healthcare law.


The White House budget office told hundreds of thousands of federal workers, the bulk of whom had been idle for the past 16 days, to be ready to return to work on Thursday.


The down-to-the-wire deal, however, offers only a temporary fix and does not resolve the fundamental issues of spending and deficits that divide Republicans and Democrats. It funds the government until January 15 and raises the debt ceiling until February 7, so Americans face the possibility of another bitter budget fight and another government shutdown early next year.


With the deadlock broken just a day before the U.S. Treasury said it would exhaust its ability to borrow new funds, U.S. stocks surged on Wednesday, nearing an all-time high. Share markets in Asia also cheered the deal.


Taking the podium in the White House briefing room on Wednesday night, Obama said that with final congressional passage, "We can begin to lift this cloud of uncertainty and unease from our businesses and from the American people."


"Hopefully next time it won't be in the 11th hour. We've got to get out of the habit of governing by crisis," Obama said. He outmaneuvered Republicans by holding firm in defense of "Obamacare" to win agreement, with few strings attached, to end the 16-day shutdown.


World Bank President Jim Yong Kim said "the global economy dodged a potential catastrophe" with congressional approval of the deal to raise the $16.7 trillion U.S. debt ceiling.


The standoff between Republicans and the White House over funding the government forced the temporary lay-off of hundreds of thousands of federal workers from October 1 and created concern that crisis-driven politics was the "new normal" in Washington.


While essential functions like defense and air traffic control continued during the crisis, national parks and agencies like the Environmental Protection Agency have been largely closed.


Senator John McCain, whose fellow Republicans triggered the crisis with demands that the Democratic president's "Obamacare" healthcare reform law be defunded, said earlier on Wednesday the deal marked the "end of an agonizing odyssey" for Americans.


"It is one of the most shameful chapters I have seen in the years I've spent in the Senate," said McCain, who had warned Republicans not to link their demands for Obamacare changes to the debt limit or government spending bill. Polls showed Republicans took a hit in public opinion over the standoff.


In the end, the Democratic-led Senate overwhelmingly passed the measure on a 81-18 vote, and the Republican-controlled House followed suit 285 to 144. Obama signed the 35-page bill just after midnight.


POLITICAL DYSFUNCTION


Although the deal would only extend U.S. borrowing authority until the first week of February, the Treasury Department would have tools to temporarily extend its borrowing capacity beyond that date if Congress failed to act early next year. But such techniques eventually run out.


In addition to lifting the federal debt limit, the deal calls for creating a House-Senate bipartisan commission to try to come up with long-term deficit-reduction ideas that would have to be approved by the full Congress. Their work would have to be completed by December 13, but some lawmakers say the panel faces an extremely difficult task.


The agreement also includes some income verification procedures for those seeking subsidies under the 2010 healthcare law. But it was only a modest concession to Republicans, who surrendered on their latest attempt to delay or gut the healthcare package or include major changes, including the elimination of a medical device tax.


The congressional vote signaled a temporary ceasefire between Republicans and the White House in the latest struggle over spending and deficits that has at times paralyzed both decision-making and basic functions of government.


The political dysfunction has worried U.S. allies and creditors such as China, the biggest foreign holder of U.S. debt, and raised questions about the impact on America's prestige. The Treasury has said it risks hurting the country's reputation as a safe haven and stable financial center.


Senate Majority Leader Harry Reid and Republican leader Mitch McConnell announced the fiscal agreement on the Senate floor earlier on Wednesday, and its passage was eased when the main Republican critic of the deal, Senator Ted Cruz of Texas, said he would not use procedural moves to delay a vote.


The agreement stacked up as a political achievement for Obama, who refused to negotiate on changes to the healthcare law, and a defeat for Republicans, who were driven by Tea Party conservatives in their ranks and suffered a backlash in public opinion polls.


There was no immediate sign that House Speaker John Boehner's leadership position was at risk despite having conceded defeat in the budget battle.


Several Republican lawmakers suggested he may have strengthened his standing among the rank-and-file, who gave him a standing ovation at an afternoon meeting.


But Cruz, a Tea Party-backed senator with 2016 presidential aspirations, denounced the fiscal accord as a "terrible deal" and accused fellow Republicans of giving in too easily in their bid to derail Obamacare.


Obama's Democrats avoided claims of victory. "The bottom line is, millions suffered, millions didn't get pay checks, the economy was dragged down," said Senator Charles Schumer. "This is not a happy day, it is a somber day."


The fight over Obamacare rapidly grew into a brawl over the debt ceiling, threatening a default that global financial organizations warned could throw the United States back into recession and cause a global economic disaster.


Fitch Ratings had warned on Tuesday that it could cut the U.S. sovereign credit rating from AAA, citing the political brinkmanship over raising the debt ceiling.


A resolution to the crisis cannot come soon enough for many companies. American consumers have put away their wallets, at least temporarily, instead of spending on big-ticket items like cars and recreational vehicles.


"We're sort of 'crises-ed' out," said Tammy Darvish, vice president of DARCARS Automotive Group, a family-run company that owns 21 auto dealerships in the greater Washington area.


(Additional reporting by Thomas Ferraro, Steve Holland, Roberta Rampton and Mark Felsenthal, Amanda Becker, Patricia Zengerle, Susan Heavey, David Lawder and Jason Lange; Writing by Matt Spetalnick; Editing by Grant McCool and Tim Dobbyn)



Source: http://news.yahoo.com/senate-passes-bill-avoid-default-reopen-government-000958311--sector.html
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World War R: New Comic Pits Archie And Friends Against The Undead





Cover of Afterlife with Archie #1.



Archie Comics

Ready for your fair share of Halloween shakes and shivers, kiddies? Look no further than Afterlife with Archie, a new ongoing comic series that melds our eternal fascination with all things zombie apocalypse and one of the most enduring and successful comic icons of all time, Archie Andrews — and yes, it is actually scary.


That's right, the perma-teenagers in happy-go-lucky Riverdale find their comforting and idealized existence invaded by ... undead hordes. Can these archetypal clean-cut kids survive? Here's the setup:


Reggie Mantle runs over Jughead's fluffy pup Hot Dog. (Of course Reggie started it!) Jughead takes Hot Dog to Sabrina the teen witch, who using the Necronomicon and channeling Pet Sematary, brings him back to life. (And messes it up, 'cause that's what she does!) Hot Dog bites Jughead, who ends up consuming victims at the Halloween Dance. (He is always hungry!)


Meanwhile sexy nurse Betty and even more sexy Vampirella — or "Vampironica," as Betty calls her, after Veronica calls Betty "Florence Nightinghag" — are too busy sniping at each other over costume choices to notice. (Naturally!)


What follows is a five-story arc called "Escape from Riverdale" that will see the surviving members of the gang leave home for the first time in 72 years. Terrific pop-culture horror references (or reverences) in dialogue and art are on every page, plus a dark humor that conjures classic Tales from the Crypt.


This new macabre monthly masterpiece is penned by Roberto Aguirre-Sacasa, who cut his teeth on horror fare and Archie comics. You might know him as the writer of the upcoming Carrie remake, or for his comic adaptation of Stephen King's The Stand. Less well known — but perhaps more relevant — is his graduate school play, originally called Archie Loves Nathan, in which Archie became college roommates with a real-life monster, Nathan Leopold (of Leopold and Loeb infamy). Afterlife is drawn by Francesco Francavilla, known for his dramatically-lit, moody creations, notably in Detective Comics. This creative combo alone put Afterlife on several most anticipated comics lists; in fact, the first issue sold out in five hours.



While Afterlife marks a lot of firsts for Archie Comics — first horror book, first teen rating — it really is the latest in a chain of successful innovations that's kept Archie on top of the mass market heap, with 2 billion comics sold in several different languages.


Did I just hear a record scratch in the minds of legions of comics readers who find the only thing enduring about Archie Andrews is his eternal squareness? Feeling smug, are you? But consider: in hairstyles, clothes, technology (there will be blood texting), Archie isn't as static as you remember.


Yes, Archie Comics keeps its core titles pristine, but it's also kept up with the times, introducing the out-and-proud character Kevin Keller along with audience-expanding mashups and alternative storylines like Archie Gets Married and Afterlife with Archie.


Remember too, your younger self had different sensibilities. 60% of Archie readers are tween girls, average starting age: nine. Since I happen to know a 9-year-old girl, Lilah, who loves Archie, I asked her what gives. "It's fun to read when I have nothing to do. Jughead is funny and all he thinks about is eating. And I like dogs. So Hot Dog is my favorite."


Dear reader, you know what I had to do. Don't hate me, don't try this at home — and don't come after me, Crypt-Keeper! But I had to ask: What did she think of Afterlife? "I really, really liked it. It was a cliffhanger. I did have a nightmare about zombies but that's just cause I read it a second time at night and it was dark so it was more scary."


Which leads me to a last reason you need to read this book if an Archie horror title wasn't on your list. The kids are going find and consume it. Why not do it together?


Source: http://www.npr.org/2013/10/18/236230146/world-war-r-new-comic-pits-archie-and-friends-against-the-undead?ft=1&f=1032
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Snowden: No classified documents taken to Russia

In this image made from video released by WikiLeaks on Friday, Oct. 11, 2013, former National Security Agency systems analyst Edward Snowden speaks during a presentation ceremony for the Sam Adams Award in Moscow, Russia. Snowden was awarded the Sam Adams Award, according to videos released by the organization WikiLeaks. The award ceremony was attended by three previous recipients. (AP Photo)







In this image made from video released by WikiLeaks on Friday, Oct. 11, 2013, former National Security Agency systems analyst Edward Snowden speaks during a presentation ceremony for the Sam Adams Award in Moscow, Russia. Snowden was awarded the Sam Adams Award, according to videos released by the organization WikiLeaks. The award ceremony was attended by three previous recipients. (AP Photo)







(AP) — Former National Security Agency systems analyst Edward Snowden says that he did not take any secret NSA documents to Russia and that intelligence officials in China as well as Russia could not get access to the documents he had obtained before leaving the United States.

In an interview with The New York Times, Snowden said he handed over all the documents he had obtained to journalists during his stay in Hong Kong. The newspaper posted its story on its website Thursday.

Snowden said he did not retain copies of the documents and did not take them to Russia "because it wouldn't serve the public interest," the Times reported. He said his familiarity with China's intelligence abilities allowed him to protect the documents from Chinese spies while he was in Hong Kong.

"There's a zero percent chance the Russians or Chinese have received any documents," he said.

Snowden's leaks of highly classified material have resulted in numerous news stories about U.S. surveillance activities at home and abroad and sparked debate about the legality of those activities and the privacy implications for average Americans.

The Times reported that in the interview, which it said took place over several days in the last week and involved encrypted online communications, Snowden asserted that he believed he was a whistle-blower who was acting in the nation's best interests by revealing information about the NSA's surveillance dragnet and huge collections of communications data.

Snowden said that he had helped U.S. national security by prompting a badly needed public debate about the scope of the intelligence effort. "The secret continuance of these programs represents a far greater danger than their disclosure," he said.

Snowden faces espionage charges in the U.S. On Aug. 1 he was granted asylum in Russia, which is allowing him to remain there for one year.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-10-17-US-NSA-Surveillance-Snowden/id-4f057cdb51194bd292a67bb704aa47ea
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Thursday, October 17, 2013

UK cost agency backs Medivation, Astellas prostate cancer pill


LONDON (Reuters) - Britain's healthcare cost watchdog NICE has recommended that a new prostate cancer pill from Medivation and Astellas should be used on the state health service.


The draft guidance is conditional on Xtandi being provided at an undisclosed discount to the list price of 2,734.67 pounds ($4,400) for 28 days supply, the National Institute for Health and Clinical Excellence (NICE) said on Friday.


Xtandi, known chemically as enzalutamide, is designed to treat advanced prostate cancer in patients who have previously received chemotherapy.


It is one of four new life-extending prostate cancer drugs that researchers from Britain's Institute of Cancer Research (ICR) have helped to develop in recent years. The others are Johnson & Johnson's Zytiga, Sanofi's Jevtana, and Xofigo from Algeta and Bayer.


Alan Ashworth, chief executive of the ICR, said these drugs offered hope for men after decades in which there had been no options once old-style hormone treatment stopped working.


"What we're seeing now is an unprecedented period of success for prostate cancer research," he said. "It truly is a golden age for prostate cancer drug discovery and development."


Zytiga is already recommended by NICE but Jevtana was rejected as not being cost-effective. The agency has yet to give its verdict on Xofigo, which is on sale in the United States but not yet launched in Europe.


($1 = 0.6278 British pounds)


(Reporting by Ben Hirschler; editing by David Evans)



Source: http://news.yahoo.com/uk-cost-agency-backs-medivation-astellas-prostate-cancer-230237668--sector.html
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Ubisoft Won't Be Letting the Watch Dogs Out

Ubisoft has decided to hold back on releasing its Watch Dogs, and The Crew won't be seeing any action until sometime well into 2014 either. While that will take some festivity out of the holiday season for the company and disappointed gamers alike, it's not all bad. "Ubisoft will have a bigger installed base of next-generation consoles to aim for when these games do launch," noted gaming analyst P.J. McNealy.


Ubisoft -- Europe's largest video game publisher -- might have a less-than-merry holiday season. It announced Wednesday that two of its hotly anticipated titles, Watch Dogs and The Crew, would be delayed until sometime in 2014.


Shares fell on the news by as much as 32 percent -- the most since Ubisoft made its debut on the Paris exchange in 1992. Ubisoft has predicted an operating loss of 40 million euros to 70 million euros for the year ending in March.


The holiday period accounted for more than half the company's sales last year.


Tough Decisions


Watch Dogs and The Crew are now expected to debut sometime between March and September of next year.



"Our long-term goal is to win the next generation," said Ubisoft cofounder and CEO Yves Guillemot.


"The tough decisions we are taking today to fully realize the major potential of our new creations have an impact on our short-term performance. We are convinced that longer term, they will prove to be the right decisions both in terms of satisfaction for our fans and in terms of value creation for our shareholders," he explained.


"We are building franchises that will become perennial pillars of Ubisoft's financial performance," Guillemot added. "In a context of growing successes for mega-blockbusters, the additional time given to the development of our titles will allow them to fulfill their huge ambitions and thus offer players even more exceptional experiences."


Game Delayed, Not Over


These are not the only high-profile game launches to be postponed, but what makes the delay of Watch Dogs especially problematic is that it had been slated as a launch title for Sony's PlayStation 4 video game console. It was included in some prerelease bundle deals for next month's PS4 debut.


The delay could cause headaches not only for Ubisoft but also for Sony.


"Game delays, especially high-end console games, are unfortunately common," Piers Harding-Rolls, director and head of games for IHS Electronics and Media, told the E-Commerce Times.


"Much like big-budget movies with unwieldy crews and post production processes, the complexity of pulling games together and the number of staff involved in their development mean that some delays are inevitable," he said.


"Ubisoft will be disappointed to miss the launch period of the next generation of consoles, especially as this is often a time when consumers are more open and interested in entirely new games properties and gameplay," added Harding-Rolls. "It's also likely that Ubisoft will have additional costs to bear associated with these delayed games, included prepaid marketing costs and development time costs."


Console Transition


Though Ubisoft could easily recover from this setback, it might be a portent that the next-generation systems -- including Sony's PS4 -- could be more challenging for game developers than had been expected. It also could be that Ubisoft would rather endure a short-term delay than risk damaging a potential cash cow franchise.


"Console transitions are always challenging, and pushing out a launch window title at this point is not unusual but is unfortunate," said video game industry consultant P.J. McNealy of Digital World Research.


"Caution is the better path at this point, because you never want to ship a new intellectual property early in the cycle if it isn't fully baked," he told the E-Commerce Times. "Near-term, this is painful for Ubisoft, but not fatal."


There is one possible bright side to this. The delay ultimately could mean bigger sales, as launch titles might not have legs beyond the launch window.


"On a more positive note, Ubisoft will have a bigger installed base of next-generation consoles to aim for when these games do launch, which will help mitigate these additional costs," noted Harding-Rolls. "We expect next generation software on PS4 and Xbox One to sell for a higher sales price than current generation software, so that will likely soften the blow."


Source: http://www.technewsworld.com/rsstory/79207.html
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The Hidden Easter Eggs That Link Star Wars and Indiana Jones

The Hidden Easter Eggs That Link  Star Wars and Indiana Jones

From a young age I was introduced to what are still two of my favourite movie franchises of all time – Star Wars and Indiana Jones. I suppose it was inevitable, really. With parents who named me after a Doctor Who character, I would expect them to continue being awesome as I grew up.

Read more...

Source: http://gizmodo.com/the-hidden-easter-eggs-which-link-star-wars-and-indian-1446924666
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Halloween candy spooks aging digestive systems! Research in fruit flies helps explain why

Halloween candy spooks aging digestive systems! Research in fruit flies helps explain why


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Public release date: 15-Oct-2013
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Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research





Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame. Working in fruit flies, scientists at the Buck Institute have identified a mechanism that helps the flies adapt to changes in diet when they're young; they've discovered that same mechanism gets misregulated as the flies age, disrupting metabolic homeostasis, or balance.


In a study appearing in Cell Reports, researchers focus on the function of the Foxo gene in the intestines of fruit flies. Foxo is widely expressed throughout the body (both in flies and in humans), particularly in muscle, the liver and pancreas and can regulate many aspects of metabolism in response to insulin signaling. Lead author Jason Karpac, PhD, Assistant Research Professor at the Buck, says when young animals experience a change in diet, insulin signaling gets repressed, which turns on Foxo. "In normal young animals Foxo turns on and off quite easily, allowing for a seamless adjustment to changes in diet," said Karpac. "The process is evolutionarily conserved, it protects young animals and helps guarantee their survival," he said.


But Karpac says as the animals age, Foxo stops responding to insulin signaling (not a good thing for non-youngsters who crave that Halloween candy). "In the flies Foxo gets chronically turned on, which disrupts lipid metabolism. The process reflects the development of a general inflammatory condition in the aging gut."


"It has been proposed that our modern high-sugar/high fat diets can lead to misregulation of evolutionarily conserved dietary responses," said Buck Institute faculty Heinrich Jasper, PhD, lead scientist on the study. "That may be the case. Metabolism is a very complex process -- lots of things can go wrong which increases stress in the animals." Jasper says age-related loss of metabolic balance is a risk factor for many human pathologies. The goal is to identify age-related changes in metabolic pathways with the hope of being able to intervene. "Our aim is to develop treatments that would preserve well-functioning metabolism as part of healthy aging something that would likely not ever include indulging in candy binges."


###


Other contributors to the study include Benoit Biteau, Department of Biology, University of Rochester, Rochester, NY. The work was supported by the National Institute on Aging (NIH RO1 AG028127) and American Federation of Age Research and the Ellison Medical Foundation.



Citation: "Misregulation of an Adaptive Metabolic Response Contributes to the Age-Related Disruption of Lipid Homeostatis in Drosophila" Cell Reports, epub, September 12, 2013.



About the Buck Institute for Research on Aging

The Buck Institute is the U.S.'s first independent research organization devoted to Geroscience focused on the connection between normal aging and chronic disease. Based in Novato, CA, The Buck is dedicated to extending "Healthspan", the healthy years of human life and does so utilizing a unique interdisciplinary approach involving laboratories studying the mechanisms of aging and those focused on specific diseases. Buck scientists strive to discover new ways of detecting, preventing and treating age-related diseases such as Alzheimer's and Parkinson's, cancer, cardiovascular disease, macular degeneration, osteoporosis, diabetes and stroke. In their collaborative research, they are supported by the most recent developments in genomics, proteomics, bioinformatics and stem cell technologies. For more information: http://www.thebuck.org




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Halloween candy spooks aging digestive systems! Research in fruit flies helps explain why


[ Back to EurekAlert! ]
Public release date: 15-Oct-2013
[


| E-mail



| Share Share

]

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research





Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame. Working in fruit flies, scientists at the Buck Institute have identified a mechanism that helps the flies adapt to changes in diet when they're young; they've discovered that same mechanism gets misregulated as the flies age, disrupting metabolic homeostasis, or balance.


In a study appearing in Cell Reports, researchers focus on the function of the Foxo gene in the intestines of fruit flies. Foxo is widely expressed throughout the body (both in flies and in humans), particularly in muscle, the liver and pancreas and can regulate many aspects of metabolism in response to insulin signaling. Lead author Jason Karpac, PhD, Assistant Research Professor at the Buck, says when young animals experience a change in diet, insulin signaling gets repressed, which turns on Foxo. "In normal young animals Foxo turns on and off quite easily, allowing for a seamless adjustment to changes in diet," said Karpac. "The process is evolutionarily conserved, it protects young animals and helps guarantee their survival," he said.


But Karpac says as the animals age, Foxo stops responding to insulin signaling (not a good thing for non-youngsters who crave that Halloween candy). "In the flies Foxo gets chronically turned on, which disrupts lipid metabolism. The process reflects the development of a general inflammatory condition in the aging gut."


"It has been proposed that our modern high-sugar/high fat diets can lead to misregulation of evolutionarily conserved dietary responses," said Buck Institute faculty Heinrich Jasper, PhD, lead scientist on the study. "That may be the case. Metabolism is a very complex process -- lots of things can go wrong which increases stress in the animals." Jasper says age-related loss of metabolic balance is a risk factor for many human pathologies. The goal is to identify age-related changes in metabolic pathways with the hope of being able to intervene. "Our aim is to develop treatments that would preserve well-functioning metabolism as part of healthy aging something that would likely not ever include indulging in candy binges."


###


Other contributors to the study include Benoit Biteau, Department of Biology, University of Rochester, Rochester, NY. The work was supported by the National Institute on Aging (NIH RO1 AG028127) and American Federation of Age Research and the Ellison Medical Foundation.



Citation: "Misregulation of an Adaptive Metabolic Response Contributes to the Age-Related Disruption of Lipid Homeostatis in Drosophila" Cell Reports, epub, September 12, 2013.



About the Buck Institute for Research on Aging

The Buck Institute is the U.S.'s first independent research organization devoted to Geroscience focused on the connection between normal aging and chronic disease. Based in Novato, CA, The Buck is dedicated to extending "Healthspan", the healthy years of human life and does so utilizing a unique interdisciplinary approach involving laboratories studying the mechanisms of aging and those focused on specific diseases. Buck scientists strive to discover new ways of detecting, preventing and treating age-related diseases such as Alzheimer's and Parkinson's, cancer, cardiovascular disease, macular degeneration, osteoporosis, diabetes and stroke. In their collaborative research, they are supported by the most recent developments in genomics, proteomics, bioinformatics and stem cell technologies. For more information: http://www.thebuck.org




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Source: http://www.eurekalert.org/pub_releases/2013-10/bifa-hcs101413.php
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